CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent.

CTX-0294885 is a new type of diaminopyrimidine pyrimidine, showing inhibitory activity against a variety of kinases. CTx-0294885 represents a powerful new reagent that can be used to analyze the kinase group signal network and can promote the development of targeted therapeutic strategies. Large-scale affinity purification based on CTx-0294885, followed by LC-MS / MS, can identify 235 protein kinases in MDA-MB-231 cells, including all members of the AKT family, while other AKT families have not been detected Spectral kinase inhibitor. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase enrichment can increase the number of kinase identifications to 261. Using CTx-0294885 in combination with a broad range of specific inhibitors of three other kinases, 799 high-confidence phosphate sites on 183 kinases can be identified, 10% of which are located in the activation loop and include BMP2K, MELK, HIPK2 and Phosphoric acid sites previously not reported on PRKDC.

T19251

C22H25Cl2N7O

474.39

CTX-0294885 hydrochloride;CTX-0294885 hydrochloride (1439934-41-4 free base)

H2O:370 mg/mL (779.95 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years