CCR1 antagonist 11 hydrochloride (A1B1) 是一种具有口服活性的CCR1拮抗剂，作用于 hCCR1、 mCCR1、 rCCR1 的IC50值分别为 0.03 μM、0.58 μM、0.32 μM。CCR1 antagonist 11 hydrochloride 可用于类风湿性关节炎等相关炎症性疾病的研究。

CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC 50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases [1].

CCR1 antagonist 11 hydrochloride(A1B1) inhibits MIP-1α-induced Ca 2+ mobilization in THP-1 cells with the IC 50 value of 1 nM [1].

The pharmacokinetic parameters of CCR1 antagonist 11 hydrochloride(A1B1) in rat Parameters PO (60 mg/kg) t 1/2 (h) 16.5 C max (μM/L) 0.85 AUC (h*ng/mL) 784 F (%) 95

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years