PD-1/PD-L1-IN 6 (compound A13) 是一种有效的PD-1/PD-L1相互作用抑制剂，其IC50为 132.8 nM。PD-1/PD-L1-IN 6 具有显著的免疫调节活性。PD-1/PD-L1-IN 6 在 Hep3B/OS-8/hPD-L1 与 CD3 T细胞共培养模型中显著提高干扰素 -γ 分泌，且无明显毒性作用。PD-1/PD-L1-IN 6 在 T 细胞-肿瘤共培养模型中恢复免疫应答。

PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC 50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model [1].

2393983-76-9

C25H26N2O3

402.49

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years