Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

222018-18-0

C115H184N30O24

2370.91

Lyn peptide inhibitor

H2O:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years