BGC-20-1531 (PGN 1531) free base 是一种有效的选择性前列腺素EP4受体拮抗剂，pKB值为 7.6。BGC-20-1531 free base 具有研究偏头痛的潜力。

BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP 4 receptor antagonist, with a pK B of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache [1].

BGC-20-1531 free base competitively antagonized PGE 2 -induced vasodilatation of human middle cerebral (pK b =7.8) and meningeal (pK b =7.6) arteries, but had no effect on responses induced by PGE 2 on coronary, pulmonary or renal arteries [1].

BGC-20-1531 free base (1-10 mg/kg; i.v.) causes a dose-dependent antagonism of the PGE 2 -induced increase in canine carotid blood flow [1]. Animal Model: Beagle dogs [1] Dosage: 1-10 mg/kg Administration: I.v. Result: Caused a dose-dependent antagonism of the PGE 2 -induced increase in canine carotid blood flow.

736183-35-0

C26H24N2O6S

492.54

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years