PGD2-inhibitor 是DP受体拮抗剂(IC50:0.3 nM)，摘自专利 WO 2006044732 A2，化合物实例 15 (d)。

PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d)

Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists have been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasal congestion.

885066-67-1

C23H23Cl2N3O3

460.36

PGD2-inhibitor;PGD2-IN-1

DMSO:25 mg/mL (54.31 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years