16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.

16,16-Dimethyl prostaglandin E2 (10 μg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2IMF-KO mice and restores epithelial proliferation and structure.

Animal Model: Tpl2I(MF-KO) mice. Dosage: 10 μg/kg. Administration: IP; every 12 hours; for 8 days [2]

39746-25-3

C22H36O5

380.52

16,16-dimethyl PGE2;16,16-Dimethyl prostaglandin E2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years