BelvaRafenib TFA (HM95573 TFA) 是一种有效的，广泛的迅速加速纤维肉瘤激酶(Raf)的抑制剂，其对 B-Raf，B-Rafv600E和C-Raf 的IC50值分别为 56 nM, 7 nM 和 5 nM。

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC 50 s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively [1].

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC 50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC 50 s of 10 nM, 23 nM and 44 nM, respectively [1].

C25H17ClF4N6O3S

592.95

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years