20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.

116477-57-7

C20H30O3

318.457

20-HEPE

DMSO:Miscible
PBS (pH 7.2):0.8 mg/mL
DMF:Miscible
Ethanol:Miscible
Powder: -20°C for 3 years
In solvent: -80°C for 2 years