StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.

300839-31-0

C14H13N3O2

255.27

StA-IFN-1

DMSO:5 mg/mL
DMF:3 mg/mL
DMSO:PBS (pH 7.2) (1:10):0.1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years