IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC 50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.

IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC 50 of 330 nM[1]. IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity[1]. IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC 50 =14,000 nM)[1].

IDO1-IN-7 (10 mg/kg; p.o.) shows C max =10.0 μM, AUC 0-8 h =27.1 μM*h, t 1/2 =1.4 h in mouse[1]. Animal Model: Mouse[1]Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: Oral administration Result: C max (10.0 μM), AUC 0-8 h (27.1 μM*h), t 1/2 (1.4 h)

2351199-98-7

C22H19ClFN3O3

427.86

IDO1-IN-7;IDO1-IN-7

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years