hCAIX-IN-8 (compound 7i) 是一种有效的选择性hCAIX抑制剂，CAII、CAIX、CAVA 的IC50s 分别为 1.99, 0.024, 1.10 μM。hCAIX-IN-8 具有低毒性的抗增殖活性。hCAIX-IN-8 减少上皮细胞向间充质细胞的转化并诱导细胞Apoptosis" style="display: inline; color: #c13a36">凋亡 (Apoptosis)。hCAIX-IN-8 抑制细胞迁移和定植。

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC 50 s of 1.99, 0.024, 1.10 μM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential [1].

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC 50 是of 8.44, 11.22 μM for HT29, HepG2 cells, respectively [1]. hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

2414633-40-0

C19H16N4O6

396.35

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years