Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy. Laminaran is a neutral water-soluble β-1-3-glucan and a typical ligand for Dectin-1 isolated from the brown alga D. dichotoma, has potent immunomodulating, radioprotective, and anticancer activities.

Laminaran (25-50 μg/mL; 24 hours) at low concentration does not effect the phosphorylation of c-Raf (Ser259), ERK1/2 (Tyr202/Tyr204), and MEK1/2 (Ser 221) kinases as well as the total expression level of investigated proteins. But decreases p-MEK, p-ERK1/2 at 50 μg/mL. Laminaran (100-800 μg/mL; 24 hours) is not cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28, the percentage of inhibition of living cells number is less than 15 % at concentrations ranging up to 800 μg/mL after 24 h of treatment. Laminaran (200 μg/mL; 24-72 hours)does not induce any growth inhibition of SK-MEL-28 cells after 24 and 48 h of treatment but decreases cell proliferation by 36 % after 72 h of treatment [1].

When it compares with the PBS-, OVA-, and laminarin-treated mice, Laminaran (intravenous injection; 12.5, 25, and 50 mg/kg; 21 days) and OVA (50 μg) combination significantly reduces the tumor masses [3].

9008-22-4

C18H35NO16

521.469

Laminaran

DMSO:100 mg/mL,Need ultrasonic
H2O:100 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years