SPD304 是一种选择性 TNF-α 抑制剂，可阻断 TNF 与其受体的相互作用。 SPD304 在体外抑制 TNF 受体 1 与 TNF-α 结合的 IC50 为 22 μM。

SPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 binding to TNF-α.

SPD304 (2 μM) obviously rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold and p–RIP3 1.4–fold compared to GA alone and promotes caspase 8 activation [4].

869998-49-2

C32H32F3N3O2

547.61

SPD304

H2O:18 mg/mL (32.87 mM),Need ultrasonic
DMSO:24 mg/mL (43.83 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years