OBX02-011 是一种有效且可逆的 EGFR 酪氨酸激酶抑制剂，对三突变体 Del19/T790M/C797S 和 L858R/T790M/C797S 的 IC50 分别为 0.134 和 2.09 nM。

OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.

OBX02-011 shows broad activity at low nanomolar concentrations against mutant EGFRs. OBX02-011 occupies the ATP-binding site in a similar manner to WZ-4002[1].

In transgenic mouse models, OBX02-011 (25 mg/kg, i. p.) effectively inhibits tumor growth and EGFR activity and leads to enhanced survival[1].

2349336-18-9

C29H39ClN8O3S

615.19

OBX02-011

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years