GAK inhibitor 49 hydrochloride 是一种 ATP 竞争性的、高选择性细胞周期蛋白G相关激酶(GAK)抑制剂，Ki为 0.54 nM，细胞IC50为 56 nM。GAK inhibitor 49 hydrochloride 也显示与 RIPK2 结合。

GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a K i of 0.54 nM and a cell IC 50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2 [1].

GAK inhibitor 49 (compound 49) hydrochloride shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC 50 s of 28, 63 and >100μM, respectively [1].

C20H23ClN2O5

406.86

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years