NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM).

NVP-CGM097 is able to significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM, demonstrating its ability to inhibit the p53:MDM2 interaction in living cells.?NVP-CGM097 significantly inhibits the proliferation of cells expressing wild-type p53, while sparing the p53 null cells with a 35-58-fold difference.?NVP-CGM097 inhibtis HCT116 (p53WT/WT) with IC50 of 454±136 nM[1].

1313367-56-4

C38H49ClN4O8S

757.34

CGM097 sulfate;NVP-CGM097 sulfate

H2O:140 mg/mL (184.86 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years