SM-433 hydrochlorid 是一种 Smac 模拟物，是一种凋亡抑制蛋白(IAPs)的抑制剂发挥作用。SM-433 hydrochlorid 表现出强结合亲和力 XIAP BIR3 蛋白，IC50<1 μM (详细信息来自专利 WO2008128171A2)。

SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC 50<1 μM (patent WO2008128171A2) [1].

SM-433 hydrochlorid exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC 50 s<10 μM, respectively) [1].

C32H44ClN5O4

598.18

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years