CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).

In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA.

2368900-32-5

C30H30N2O7

530.57

CMLD012073

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years