PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.

2163793-38-0

C45H45BrN6O8S

909.84

PROTAC Mcl1 degrader-1

DMSO:50 mg/mL (54.95 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years