Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.

Deformyl fluorobromobromide hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with a pEC50 of 6.48. In high-sensitivity (HS) and low-sensitivity (LS) isomer preparations, norformyl fluoroethyl bromide hydrochloride can enhance and inhibit the current induced by ACh, although compared to the HS isomer, the deformyl hydrochloride Fluoroethyl bromide hydrochloride has a higher effect on the LS isomer (pEC50 = 6.4 ± 0.2) (pEC 50 = 5.6 ± 0.2). Norformyl fluoride ethyl bromide hydrochloride can maximize the response induced by ACh using wild-type receptor expressed by HS isoform preparation, up to 350±20%, which is the same as that received by LS isoform preparation. The body (350±30%) is similar.

951322-11-5

C16H22BrClN2

357.72

dFBr hydrochloride;Deformylflustrabromine hydrochloride;Desformylflustrabromine hydrochloride

H2O:5 mg/mL (13.98 mM),Need ultrasonic
DMSO:105 mg/mL (293.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years