MSC2504877 是一种tankyrase 抑制剂，可增强临床CDK4/6 抑制剂的作用。 MSC2504877 抑制由 palbociclib 引起的 Cyclin D2 和 Cyclin E2 的上调，并增强对 phospho-Rb 的抑制。

MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.

1460286-21-8

C17H18N2O2

282.34

3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one;MSC2504877

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years