AX20017是蛋白激酶G的一个小分子抑制剂，IC50值为 0.39 μM。

AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.

The inhibitory activity of AX20017 against the 11 known mycobacterial kinases revealed that the compound is highly selective for PknG . To test the activity of the inhibitor toward eukaryotic kinases, a screen of 28 different archetypical human kinases originating from six major protein kinase groups was set up. AX20017 did not affect the human kinases, whereas the activity of PknG was effectively inhibited[1].

329221-38-7

C13H16N2O2S

264.34

AX20017

DMSO:32 mg/mL (121.06 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years