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BM635
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BM635图片
CAS NO:1493762-74-5
包装与价格:
包装价格(元)
25 mg电议
50 mg电议

产品介绍

产品描述

BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).

体内活性

BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity (ED99: 49 mg/Kg; IC95%: 43–54 mg/Kg) [1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax: 1.62 μM) and a moderate bioavailability (46%) [2].

Cas No.

1493762-74-5

分子式

C25H29FN2O

分子量

392.51

别名

BM635

储存和溶解度

DMSO:31 mg/mL (78.98 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years