ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation.

ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4]. ATP dipotassium promotes neutrophil chemotaxis in vitro[4].

ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4]Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial ( E. coli ) challenge Result: Protected mice from bacterial infection.

42373-41-1

C10H16KN5O13P3

546.28

Adenosine5'-triphosphatedipotassium;腺苷三磷酸二钾盐;ATP dipotassium

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years