KDM1/CDK1-IN-1 (compound 4) 是一种有效的KDM1和CDK1抑制剂，IC50值分别为 0.096 和 0.078 μM。KDM1/CDK1-IN-1 诱导 HOP-92 细胞周期阻滞在 G2/M 期并诱导Apoptosis" style="display: inline; color: #c13a36">凋亡 (Apoptosis)。KDM1/CDK1-IN-1 对 CCRF-CEM、HOP-92 和 Hep-G2 细胞表现出较强的细胞毒性活性，IC50分别为 16.34、3.45 和 7.79 μM。

KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC 50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC 50 values of 16.34, 3.45 and 7.79 μM, respectively [1].

KDM1/CDK1-IN-1 (compound 4) induces apoptosis by the activation of Caspase-3 [1].

C22H17N5O3S

431.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
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In solvent: -80°C for 2 years