A61603 is a novel, potent and selective α1A(alpha1A)-adrenoceptor agonist that has been studied to understand the functional roles of α(1)-adrenoceptor subtypes in mouse carotid arteries. A61603 was the most potent alpha-1-agonist in activating ERK in neonatal rat ventricular myocytes. A61603 activated ERK in adult mouse ventricular myocytes and protected the cells from death caused by the anthracycline doxorubicin. A low dose of A61603 (10 ng/kg/d) activated ERK in the mouse heart in vivo, but did not change blood pressure.

纯度：≥98%

CAS：750531-54-5