Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models.

Tin-protoporphyrin IX with 20 μM, 50 μM and 24 hours, significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast.

Tin-protoporphyrin IX (5 mg/kg; at 0, 7, 15, and 20 days) intraperitoneal injection alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P< 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.

14325-05-4

C34H31Cl2N4O4Sn

749.25

SnPPIX;锡原卟啉IX;Tin-protoporphyrin IX

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years