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MMG-11 quarterhydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
100 mg电议
200 mg电议

产品介绍
MMG-11 quarterhydrate 是一种有效的选择性人TLR2拮抗剂。MMG-11 quarterhydrate 抑制 TLR2/1 和 TLR2/6 信号转导,抑制 Pam3CSK4诱导的 hTLR2/1,IC50为 1.7 μM,抑制 Pam2CSK4诱导的 hTLR2/6 反应,IC50为 5.7 μM。

产品描述

MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC 50 s of 1.7 μM for Pam 3 CSK 4 -induced hTLR2/1 and 5.7 μM for Pam 2 CSK 4 -induced hTLR2/6 responses [1].

体外活性

MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 μM) shows no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs) [1]. Cell Cytotoxicity Assay [1] Cell Line: PBMCs Concentration: 0.01, 1, 10, 100 μM Incubation Time: Result: Showed no cytotoxic effects up to 100 μM.

分子式

C15H16O8

分子量

310.78

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years