D-3263 hydrochloride 是一种具有口服活性的 TRPM8 激动剂。

D-3263 hydrochloride is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.

D-3263 hydrochloride binds and activates TRPM8, which may lead to increased entry of calcium and sodium; destruction of calcium and sodium homeostasis; induction of cell death in tumor cells expressing TRPM8. D-3263 hydrochloride may reduce the level of dihydrotestosterone (DHT), which may contribute to its inhibitory effect on prostate cancer and BPH[1].

1008763-54-9

C21H32ClN3O3

409.95

EC D-3263 HCl;D3263 HCl salt;D-3263 hydrochloride

DMSO:35 mg/mL (85.4 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years