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Nefopam HCl(Fenazoxine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nefopam HCl(Fenazoxine)图片
CAS NO:23327-57-3
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)289.8
FormulaC17H19NO.HCl
CAS No.23327-57-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 21 mg/mL (72.5 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride

InChi Key: CNNVSINJDJNHQK-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

SMILES Code: CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1.[H]Cl

Synonyms

Leoplexamin; Nefopam HCl; Nefopam hydrochloride; Fenazoxine hydrochloride; Lenipan; Oxadol; Pallopikeron, Brand name Acupan

实验参考方法
In Vitro

In vitro activity: The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine.

In VivoUsing the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick.
Animal modelMice
Formulation & Dosageintraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection
References

Br J Anaesth. 2008 Nov;101(5):610-7.