Glutamate-5-kinase-IN-2 (compound 54) 是一种有效的glutamate-5-kinase (G5K)抑制剂，MIC (最小抑制浓度)为 4.2 μM. Glutamate-5-kinase-IN-2 通过促进 L-谷氨酸结合位点的构象变化来抑制 G5K 活性。Glutamate-5-kinase-IN-2 具有抗结核药物研究的潜力。

Glutamate-5-kinase-IN-2 (compound 54) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.2 μM. Glutamate-5-kinase-IN-2 shows G5K inhibition by promotes conformational changes at the L-glutamate binding site. Glutamate-5-kinase-IN-2 has the potential for the research of anti-TB agents [1].

Glutamate-5-kinase-IN-2 (compound 54) (40 μM) inhibits G5K activity with an I 0.5 of 33 μM at 10 mM concentration of L-Glu and ATP [1]. Glutamate-5-kinase-IN-2 (5, 10, 20 μM) shows no relevant cytotoxicity in HepG2 cells [1].

C17H10ClFN2

296.73

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years