GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment showed that GSK256471 reduced the E(Max) response induced by neurokinin B, indicating insurgable antagonist pharmacology (PA (2)=9.2). GSK256471 may be a promising candidate for the treatment of schizophrenia.

1133706-08-7

C29H29N3O3S

499.62

GSK 256471;GSK-256471;GSK256471

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years