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Tolperisone HCl(AV 650)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tolperisone HCl(AV 650)图片
CAS NO:3644-61-9
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)281.82
FormulaC16H23NO.HCl
CAS No.3644-61-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 56 mg/mL (198.7 mM)
Water: 56 mg/mL (198.7 mM)
Ethanol: 56 mg/mL (198.7 mM)
Other info

Chemical Name: 2-Methyl-3-piperidino-1-p-tolylpropan-1-one hydrochloride

InChi Key: ZBUVYROEHQQAKL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H

SMILES Code: O=C(C1=CC=C(C)C=C1)C(C)CN2CCCCC2.[H]Cl

Synonyms

Tolperisone HCl; Tolperisone hydrochloride; AV 650; N-553; AV-650; N553; AV650; N553; Midocalm; Muscalm; Mydocalm.

实验参考方法
In Vitro

In vitro activity: Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants.

In Vivo
Animal model
Formulation & Dosage
References

Eur J Pharmacol. 2006 May 24;538(1-3):5-14; Pain. 1996 Oct;67(2-3):417-25.