| CAS NO: | 3644-61-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 281.82 |
|---|---|
| Formula | C16H23NO.HCl |
| CAS No. | 3644-61-9 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 56 mg/mL (198.7 mM) |
| Water: 56 mg/mL (198.7 mM) | |
| Ethanol: 56 mg/mL (198.7 mM) | |
| Other info | Chemical Name: 2-Methyl-3-piperidino-1-p-tolylpropan-1-one hydrochloride InChi Key: ZBUVYROEHQQAKL-UHFFFAOYSA-N InChi Code: InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H SMILES Code: O=C(C1=CC=C(C)C=C1)C(C)CN2CCCCC2.[H]Cl |
| Synonyms | Tolperisone HCl; Tolperisone hydrochloride; AV 650; N-553; AV-650; N553; AV650; N553; Midocalm; Muscalm; Mydocalm. |
| In Vitro | In vitro activity: Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Pharmacol. 2006 May 24;538(1-3):5-14; Pain. 1996 Oct;67(2-3):417-25. |
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