FAUC 365 是一种高度选择性的多巴胺D3受体拮抗剂,能够作用于 D3 受体(Ki:0.5 nM)、D4.4 受体(Ki:340 nM)、D2short 受体(Ki:2600 nM)和 D2Long 受体(Ki:3600 nM)。它可用于研究帕金森病、精神分裂症等疾病。
产品描述
FAUC-365 is a D3 dopamine receptor agonist.
体外活性
As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively [1].
Cas No.
474432-66-1
分子式
C23H25Cl2N3OS
分子量
462.43
别名
FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-
phenyl)-piperazin-1-yl]-butyl}-amide;FAUC-365
储存和溶解度
EtOH:insoluble
DMSO:5.79 mg/mL
H2O:insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years