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Diclofensine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diclofensine hydrochloride图片
CAS NO:34041-84-4
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
200 mg电议

产品名称
Ro 8-4650 hydrochloride
4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐
产品介绍
Diclofensine hydrochloride 是一种高效单胺再摄取抑制剂,在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。

产品描述

Diclofensine hydrochloride is a Novel Antidepressant, on Peripheral Adrenergic Function

体外活性

The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE).?The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake.?PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI).?In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1].

Cas No.

34041-84-4

分子式

C17H18Cl3NO

分子量

358.69

别名

Ro 8-4650 hydrochloride;4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐;Diclofensine hydrochloride

储存和溶解度

H2O:52 mg/mL (144.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years