Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).

The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells(Kd of 480 nM)[2].

In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1].

85175-67-3

C26H36N2O5

456.57

UL-FS-49CL free base;UL-FS-49 free base;Zatebradine

DMSO:50 mg/mL (109.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years