KL201 是一种昼夜节律调制器，是CRY1选择性的 稳定剂， 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。

KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1].

KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc while not affecting cellular viability[1]. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1]. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1].

302939-48-6

C17H14BrN3OS

388.28

KL201

DMSO:250 mg/mL (643.87 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years