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AAK1-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1802703-20-3
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
AAK1-IN-3 是一种喹啉类似物,一种可透过血脑屏障的适配蛋白 2 相关激酶 1 (AAK1) 抑制剂,IC50为 11 nM。AAK1-IN-3 具有用于神经病理性疼痛研究的潜力。

产品描述

AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC 50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research [1].

体外活性

AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3 [1]. AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM) [1].

体内活性

AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice [1].

Cas No.

1802703-20-3

分子式

C20H20N4

分子量

316.4

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years