BMT-124110 is an effectivet, selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE; IC50: 17 nM) and Cyclin G-associated kinase (GAK; IC50: 99 nM).

BMT-124110 shows a cellular IC50 of 3.2 nM for AAK1.

BMT-124110 is added directly onto the spinal covered by microiontophoresis, leading to a reduction in windup-induced activity in 10 of 14 animals.

1679371-59-5

C21H27N3O3

369.46

BMT-124110

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years