GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].

CCG258208 hydrochloride

H2O:50 mg/mL (102.26 mM),Need ultrasonic
DMSO:250 mg/mL (511.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years