Z944 是有效的T型钙通道拮抗剂，对跨模态和视觉识别记忆障碍有缓解作用。

Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.

Z944 dose dependently (1, 3, 10mg/kg; i.p.) altered CMOR memory in GAERS compared to the non-epileptic control (NEC) strain. GAERS demonstrated recognition memory deficits in the visual and crossmodal variations of the CMOR task that were reversed by the highest dose of Z944. Electroencephalogram recordings determined that deficits in CMOR memory in GAERS were not the result of seizures during task performance. In contrast, NEC showed a decrease in CMOR memory following Z944 treatment[2].

1199236-64-0

C19H27ClFN3O2

383.89

Z 944;Z-944;Z944

DMSO:13 mg/ml (33.86 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years