QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.

2132411-21-1

C19H19N5O2

349.39

QD-394

DMSO:PBS (pH 7.2) (1:20):0.04 mg/mL
DMSO:5 mg/mL
DMF:1 mg/lm
Ethanol:1 mg/lm
PBS (pH 7.2):Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years