(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM.[5]11(12)-EET (50 μg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation[6] It also has anti-inflammatory, angiogenic, and cardioprotective properties[7]

123931-40-8

C20H32O3

320.473

(±)11(12)-EET

PBS (pH 7.2):>1 mg/mL (from 13(S)-HODE)
DMF:>50 mg/mL (per Rao Maddipati)
Ethanol:>50 mg/mL (per Rao Maddipati)
DMSO:>50 mg/mL (per Rao Maddipati)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years