6-Hydroxypurine 是嘌呤衍生物。6-Hydroxypurine 是潜在的自由基发生器，能够作为缺氧指征的指示剂。

Hypoxanthine, a purine derivative, is a potential free radical generator. It has been used in studies as in indicator, along with uric acid and allantoin, of in vivo free radical reactions.

Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary additive in a certain cell, bacteria, and parasite cultures as a substrate and nitrogen source. [1]

A linear increase of plasma hypoxanthine with duration of hypoxemia is found in pigs, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. Moreover, there is a direct relationship between survival time and an increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62). All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine, thus, reflected the prognosis of acute hypoxia in contrast to base deficit[1].

68-94-0

C5H4N4O

136.114

Purin-6-ol;6-羟基嘌呤;6-Hydroxypurine;Sarcine;Sarkin;Hypoxanthine

DMSO:10 mM
Ethanol:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years