JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST. JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug.

2079938-92-2

C22H29N3O7

447.48

JHU395

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years