Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro.

154303-05-6

C217H341N71O74S9

5417.1

Echistatin, α1 isoform;Echistatin

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years