AMPK-IN-3 (化合物 67) 是一种强效的、选择性的AMPK抑制剂，其对AMPK (α2)、AMPK (α1)和KDR的IC50值分别为 60.7、107 和 3820 nM。AMPK-IN-3 对AMPK的抑制不影响细胞活力或导致 K562 细胞的明显细胞毒性。AMPK-IN-3 可用于癌症的研究。

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC 50 s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer [1].

AMPK-IN-3 (100 nM) shows inhibition values for AMPK(α2), FLT1, JAK1 JH2-pseudokinase and AMPK(α1) for 64%, 43%, 41% and 29%, respectively [1]. AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 μM; 2 h) decreases the level of p-ACC in K562 cells [1]. AMPK-IN-3 (1-100 μM; 24, 48, 72 h) shows potent inhibition of cellular AMPK activity but not affect cell viability [1]. Cell Viability Assay [1] Cell Line: K562 cells Concentration: 0.195313, 0.78125, 3.125, 12.5, 50 μM Incubation Time: 2 h Result: Decreased cellular levels of p-ACC(Ser79) in K562 cells. Cell Viability Assay [1] Cell Line: K562 cells Concentration: 1-100 μM Incubation Time: 24, 48, 72 h Result: Showed no measurable impact on cell viability in K562 cells cultured under hypoxic conditions for 72 hours.

2417674-27-0

C25H33N5O3

451.56

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years