AG 1406 是受体酪氨酸激酶 VEGF 受体 2 的选择性抑制剂。

AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.

The cells are incubated in SIT buffer containing 0.25% bovine serum albumin and 250 μg/mL bacitracin and 125I-BA1 (100,000 cpm) is added, as well as various concentrations of unlabelled competitor (ML-18). After incubation at 37°C for 30 min, free 125I-BA1 is removed by washing 3 times in buffer and the cells which contain bound 125I-BA1 is dissolved in 0.2 N NaOH and counted in a gamma counter. The IC50 is calculated for each unlabeled competitor.

71308-34-4

C16H18N2O

254.333

AG 1406

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years