Steroid sulfatase-IN-4 (Compound 16) 是一种不可逆的类固醇硫酸酯酶 (STS) 抑制剂，对人 STS 的IC50为 25 nM，可用于子宫内膜异位的研究。

Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase ( STS ) inhibitor with an IC 50 of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis [1].

Steroid sulfatase-IN-4 (Compound 16) shows good metabolic stability in human hepatic S9 fraction and low intrinsic clearance Clint (<30 μL/min/mg protein) [1]. Steroid sulfatase-IN-4 (20 μM; 24 h) shows cytotoxicity for HEK-293 cells (53.6% inhibition) [1]. Steroid sulfatase-IN-4 (1 μM) shows 25% inhibition against human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in a cell-free assay [1].

C19H17ClN2O5S

420.87

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years